Takeda expects substantial cost synergies of at least $1.4 billion.
The acquisition would be the largest ever for a Japanese company, and would vault Takeda into the top 10 of global pharmaceutical giants.
Susan Kilsby, the chairwoman of Shire, said: "Over the last 30 years, Shire has become the global leader in treating rare diseases".
The tie-up crowns a hectic few months of M&A activity as big drugmakers look to improve their pipelines by bringing in promising medicines developed by younger companies.
"I think it is a good deal for Shire shareholders but not everybody may think that".
Shire shareholders will own about half of the combined group after the deal, which will be the biggest in the sector since 2000 if approved by shareholders.
The offer represents a 59.6-per cent premium to Shire's closing price of £30.70 on 27 March, before the Takeda revealed its interest in the company.
IMD warns of thunderstorms in 13 states today
Eight people were killed in Telangana, six in Uttarakhand and two in Punjab; almost 100 people were injured in the three states. The MeT department warned of thunderstorm accompanied by squall and hailstorm in the mid and lower hills on May 7 and 8.
Takeda, founded in Osaka in 1781, wants Shire, a specialist in the treatment of rare conditions, to help it expand globally - especially in the United States - as it faces down the prospect of weaker drug prices in its home market.
After waging a lengthy campaign to win over the board of Dublin-based Shire, Takeda announced Tuesday that they had an agreement. The combined company will be headquartered in Japan, but Takeda said it will boost its research and development presence in the Boston area, where both companies have sites.
"The commitment to get down to two times EBITDA in three to five years really shows how cash-generative Shire is", said Polar Capital's Mahony.
The combination merges Shire's portfolio of treatments for rare diseases with Takeda's for cancer, gastroenterology and neuroscience.
"There is 25 percent (of the portfolio) which is more isolated products".
Shire has offered Takeda a large presence in the USA and an expertise in the rare diseses.
The company traces its roots back to 1986, when it began as a seller of calcium supplements to treat osteoporosis, operating from an office above a shop in Hampshire, southern England. A quarter of Shire's product revenues previous year came from sales of its hemophilia medicines, which face competition from Roche's Hemlibra (emicizumab) now and potentially curative gene therapies in the future.
Shabana Azmi who is a very close friend of Boney and Anil Kapoor would have to miss the big day in Anil's daughter Sonam's life . As the rumour suggests, Sonam Kapoor and Meghan Markel, both will be wearing an outfit created by the same designer.
Chandler Police say the incident happened Friday afternoon when a Honda sedan swerved to avoid hitting another auto . The Waymo van was reportedly hit by sedan after it swerved into the wrong lane in order to avoid another collision.
The fifth of may celebrates the day the Mexican Army beat France at the battle of Puebla during the Franco-Mexican War. Cinco de Mayo is not Mexico's independence day from Spain, which occurred in 1810 and is celebrated on September 16.
Soon, Hardik landed another blow on Kolkata, sending Rana back to the dug out in the 14th over with Kolkata reeling at 115/4. Hardik Pandya's excellent batting towards the end along with superb bowling helped Mumbai Indians win this important match.
At 0716 GMT, June WTI crude oil is trading $70.30, up $0.58 or +0.86% and July Brent crude oil is at $75.40, up $0.53 or +0.71%. The global benchmark crude, which is at the highest level since November 2014, was at a $5.43 premium to July WTI .
It says isolated tornadoes are possible. "Slight" is the second-lowest risk category and "marginal" is the lowest used by the SPC. Across the central US , heavy rain, lightning and strong winds tore through homes and knocked down power lines.
But having been left out of the Sky team to ride the Giro past year , Viviani wasn't going to let lightning strike twice. Here it's been the complete opposite. "I think the third week and even the second week is still a big unknown for me.
The former New York City mayor also said that Mueller's team keeps "undermining" the potential for talk to Trump with them. A weekly recap of the top political stories from The Globe, sent right to your email.
The vote will usher in the powerful executive presidency approved in last April's referendum-a new chapter in Turkish politics. Ince stated that he would take the country back to the parliamentary system if he gets elected as president.
The Face ID issue doesn't appear to be widespread, but if you're experiencing any problems, you should have your device checked. The tech giant reportedly has sent a support document to retailers and authorised service centres addressing this issue.
Barca, already crowned champions , remain 15 points ahead of Real in the table but this clash was about more than just points. Barcelona fans create a mosaic reading 'champions!' in Catalan before the match.
Benzema sends Real into Champions League final
Benzema hasn't been playing regularly as a starter and was a surprise addition to the lineup by Zidane. Real Madrid coach Zinedine Zidane is delighted with the form of Keylor Navas and Karim Benzema .
Mets designate Harvey for assignment
In the three seasons since, Harvey has limped to a 5.93 ERA with a pedestrian 6.9 K/9 against 3.4 BB/9 over just 212 1/3 frames. It has been more than two years since Matt Harvey was the reliable, forget dominant, starter the New York Mets once hailed.